NMR & Quantum Hyperpolarization

SABRE(Signal Amplification by Reversible Exchange)를 포함한 파라수소 기반 초분극 기술과 NV center를 활용한 초분극 시스템을 연구하여 NMR 신호 감도를 획기적으로 향상시키는 연구를 수행하고 있습니다. 이를 통해 극미량 화학물질 검출과 기존 NMR 방식으로는 접근하기 어려운 분자 구조 탐색의 새로운 경로를 개척하고 있으며, 촉매 설계, 초분극 전달 메커니즘, 그리고 대사체학 및 화학물질 검출 응용 분야까지 연구 범위를 확장하고 있습니다.

We investigate parahydrogen-based hyperpolarization techniques, including SABRE (Signal Amplification by Reversible Exchange) and NV center-based hyperpolarization techniques, to dramatically enhance NMR signal sensitivity. This research opens new pathways for detecting trace-level chemicals and probing molecular structures that are otherwise inaccessible by conventional NMR methods. Our work spans catalyst design, hyperpolarization transfer mechanisms, and applications in metabolomics and chemical detection.

<최근 논문>

- A computational protocol for 15 N NMR parameter prediction in aqueous peptide ensembles using optimized DFT methods

Minji Kim, Jung Ho Lee*, Keunhong Jeong*

Physical Chemistry Chemical Physics, 28, 28-32 (2026)

- Parahydrogen-induced hyperpolarization of a Zn(II) complex using NMR signal amplification by reversible exchange (SABRE)

Jisu Kim, Hye Jin Jeong, Sein Min, Sarah Kim, Juhee Baek, Jaelim Kim, Eunsung Lee,* Sangwon Oh* and Keunhong Jeong*

Chemical Communications, 61(59), 11061-11064 (2025)

- Temperature-Sensitive Magnetic Resonance Probes: Leveraging Hyperpolarized Pyridine-2-Carbaldehyde and SABRE for Real-Time Temperature Sensing

Sein Min, Hye Jin Jeong, Sarah Kim, Juhee Baek, Jisu Kim, Jean Chung, Sung Keon Namgoong, Keunhong Jeong*

Analytical Chemistry, 96(47), 18790 (2024) (Cover paper)